The show's creator Cynthia Mort said in a statement, "Given the considerable amount of time that has passed and despite the best efforts of everyone involved, we were unable to find the direction of the show for the second season."
"There are so many other stories to tell and many other ways to tell them. I look forward to doing that with HBO in the future."
The cable channel picked up the series for a second season last October, but the show had yet to resume production.
"Tell Me You Love Me" centered on the lives of three couples and their problems concerning intimacy. They seek the help of a therapist, who has issues with her own relationship.
The casts included Jane Alexander, David Selby, Michelle Borth, Luke Kirby, Tim DeKay, Ally Walker and Sonya Walger.